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We employed Pearson correlation and simple linear regression models to investigate the correlations between potential biomarkers and clinical parameters of ALS patients (Additional file 5: Table S7)

The mean MELD at baseline is 11.3

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The functional activity of FVII from supernatants of iPSC-HO was assessed by two methods: a) western blotting after activation with tissue factor (TF, STA Neoplastin) and CaCl 2 and incubation with antithrombin (AT), purified from human plasma, (Grifols, Spain) and unfractionated heparin (Hospira) to measure the ability of FVII to become active and form a complex with AT